The reference site for Olanzapine

Olanzapine (originally branded Zyprexa) is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder.

WHAT IS Olanzapine?

Olanzapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

This medication is used to treat psychotic mental disorders, such as schizophrenia, bipolar disorder, and agitation that occurs with schizophrenia and bipolar mania.

Olanzapine should not be administered to treat behavioral problems in older adult patients who have dementia.

 

Brand Name(s): Zyprexa; Zydis
CAS nº: 132539-06-1
(oh-LAN-za-peen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to olanzapine and its correct use. Please read them carefully.

FDA Information

Olanzapine was approved by the FDA in 1996.

Olanzapine was the second atypical antipsychotic to gain approval by the Food and Drug Administration and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder.

It has also been established in treating depression off-label because of its mood-stabilizing properties and its ability to increase the efficacy of antidepressants.

Why is this medication prescribed?

Olanzapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Furthermore, this medication is used to treat psychotic mental disorders, such as schizophrenia, bipolar disorder, and agitation that occurs with schizophrenia and bipolar mania.

Olanzapine is sold as Zyprexa®, Zydis®, or in combination with fluoxetine, as Symbyax®.

This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

Other uses for this medicine

Olanzapine is also sometimes used for the treatment of other emotional or behavioral problems like maniac-depressive illness.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition before ever taking it.

Dosage and using this medicine

Take olanzapine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Swallow each tablet with a full glass of water. Olanzapine can also be taken with or without food.

Olanzapine is usually taken once a day. Please follow your doctor’s instructions.

Olanzapine is also available in an injectable dose form that is usually administered intramuscularly by a health care provider. Talk to your healthcare provider if you have any questions regarding the administration of injectable olanzapine.

It is important to take olanzapine regularly to get the most benefit.

Do not stop taking olanzapine without first talking to your doctor. It may be 4 weeks or more before you begin to feel better, and you may require continuous treatment for quite some time. Talk to your doctor before you stop taking this medication.

When taking orally-disintegrating tablets (Zyprexa® and Zydis®):

Using dry hands, open the sachet and peel back foil on blister. Do not push tablet through foil.

Immediately upon opening the blister, remove the tablet and place it in the mouth.

Tablet disintegration occurs rapidly in saliva so it can be easily swallowed with or without liquid.

What special precautions should I follow?

BEFORE TAKING OLANZAPINE:

Tell your doctor if you have either a liver disease or other problems with your liver; heart disease or other heart problems such as high blood pressure, a previous heart attack, or irregular heartbeats; seizures or epilepsy; diabetes; ever been diagnosed with breast cancer; an enlarged prostate or difficulty urinating; or glaucoma.

You may not be able to take olanzapine, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

Hyperglycemia (increased blood sugar) has been reported in patients treated with atypical antipsychotics including olanzapine. Talk to your doctor if you experience any signs of hyperglycemia including excessive thirst, frequent urination, excessive hunger, or weakness.

The orally disintegrating tablet (Zyprexa® and Zydis®) form of this medication contains phenylalanine. Talk to your doctor before using this formulation if you have phenylketonuria (PKU).

Olanzapine is in the FDA pregnancy category C. This means that it is not known whether olanzapine will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Furthermore, it is not known whether olanzapine passes into breast milk. Do not take olanzapine without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Possible side effects from using olanzapine may include:

agitation
behavior problems
difficulty in speaking or swallowing
restlessness or need to keep moving
stiffness of arms or legs
trembling or shaking of hands and fingers

Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness
dizziness
restlessness
unusual behavior
depression
difficulty falling asleep or staying asleep
weakness
difficulty walking
constipation
weight gain
dry mouth
pain in arms, legs, back, or joints
diarrhea

If you experience any of the following symptoms, call your doctor immediately:

seizures
fainting
shaking of hands that you can not control
changes in vision
uncontrollable movements of your arms, legs, tongue, face, or lips
fever
very stiff muscles
excess sweating
fast or irregular heartbeat
unusual bleeding or bruising
loss of appetite
upset stomach
yellowness of the skin or eyes
pain in the upper right part of the stomach
flu-like symptoms
lack of energy

Olanzapine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed and, if you have any doubts, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

drowsiness
agitation
aggressiveness
slurred speech
increased heart rate
vomiting
chest pains
trouble breathing
convulsions

Product Images

PICTURES OF OLANZAPINE PILLS

Below you will find images and specific information on the principal types of olanzapine that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: ZYPREXA®
Strength(s): 2.5 MG
Imprint: LILLY 4112
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 5 MG
Imprint: 5
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 5 MG
Imprint: LILLY 4115
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 7.5 MG
Imprint: LILLY 4116
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 10 MG
Imprint: 10
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 15 MG
Imprint: LILLY 4415
Manufacturer: ELI LILLY & Co.

Name: ZYPREXA®
Strength(s): 20 MG
Imprint: LILLY 4420
Manufacturer: ELI LILLY & Co.

 

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